The Autologous
Bio-stimulating Gel
The ULTIMATE blood concentrate just got even better! EZYGEL represents a breakthrough in natural regenerative medicine.
What is EZYGEL?
EZYGEL is a 100% autologous and natural gel material, obtained through centrifugation of a whole blood sample to isolate beneficial cells, then subjected to a cooling and heating process, without any chemical addition or modification.
By heating plasma, particularly HSA (Human Serum Albumin), we modify its rheological properties. Temperature variation is the most natural way to create an intermolecular bond, without using any additives such as BDDE for cross-linking.
EZYGEL is created by combining this heated plasma gel and EZYPRF concentrate at a 2:1 ratio.
Understanding EZYPRF Technology
EZYPRF is the foundation of our revolutionary gel technology. Through low-speed centrifugation, we capture more beneficial cells while maintaining their natural integrity.
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Low Speed Centrifugation
Gentle processing preserves cell viability and function
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More Cells
Higher concentration of beneficial platelets and growth factors
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100% Natural
No additives or chemical modifications
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Fibrin Scaffold
Natural matrix for tissue regeneration
Meet Human Serum Albumin (HSA)
Shaped very much like a heart, serum albumins are the most abundant proteins in blood, constituting nearly 60% of blood plasma proteins. This is the star protein of our new protocol.
We'll illustrate denaturation and take a deep look at this protein's reaction to temperature (unfolding). Understanding HSA's behavior is crucial to understanding how EZYGEL works.
Denaturation
When a protein loses its biomolecular structure, transitioning from folded to unfolded state
Unfolding/Refolding
Reversible denaturation under certain temperature conditions
Aggregation
Forming a cluster of components that have come together
Self-Assembly
Process where disordered components form an organized structure
Melting Point
Temperature at which the protein denatures (TM)
Understanding Protein Unfolding
Protein unfolding is a fascinating process that's key to EZYGEL's effectiveness. Think of it like a paper clip—when folded, proteins flow freely in plasma. When unfolded, they begin to aggregate and self-assemble into organized structures.
Proteins flow freely in plasma without tangling
Temperature triggers unfolding and aggregation
Organized structures form the EZYGEL foundation
In their folded state, proteins can move around freely without tangling. Once unfolded through controlled heating, they start aggregating and assembling in an organized structure—this is called self-assembly of proteins, the foundation of EZYGEL's gel formation.
Why 75°C?
The temperature behavior of Albumin has been studied for over 50 years. Scientific research reveals the precise thermal dynamics that make EZYGEL possible.
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56°C - Domain II Denaturation
Thermal denaturation begins sequentially with domain II
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62°C - Domain I Denaturation
Domain I reaches its melting point
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65°C - β-Sheet Formation
More β-sheet structures form, correlating with protein aggregation
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70°C - Self-Assembly Begins
HSA undergoes self-assembly to form fibrillar structures
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74°C - Slow Irreversibility
Below this temperature, the irreversible process rate is very slow
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75°C - Optimal Point
Hydrodynamic radius increases four times, creating more volume
Conclusion: At 75°C (167°F), our proteins' self-assembly is irreversible, but we haven't overcooked them. This is the sweet spot for EZYGEL formation.
Published Scientific Literature
EZYGEL is backed by decades of scientific research on Human Serum Albumin behavior and thermal denaturation. extensive published literature supports our technology.
Natural, Regenerative and Bio-Stimulating Gel (2022)
Kian Karimi MD, FACS, and Anil Rajani, MD
Temperature Behavior of HSA (1979)
Rolf Wetzel, Manfred Becker, et al.
Reversible Denaturation of HSA (1972)
Knut Wallevik, University of Oregon
Native to Unfolded Aggregated State (2014)
Nirmal Kumar Das, Narayani Ghosh, et al.
The EZYGEL Advantage
EZYGEL represents the next evolution in autologous regenerative treatments, combining cutting-edge science with natural biological processes.
100% Natural
No chemical additives or modifications—just your body's own healing power enhanced through precise temperature control
Autologous Safety
Using your own blood eliminates risks of allergic reactions or rejection, ensuring maximum safety and compatibility
Bio-Stimulating
Activates natural regeneration processes for long-lasting, natural-looking results that improve over time
Science-Backed
Built on 50+ years of research on protein behavior and thermal dynamics, with ongoing clinical studies
Get in Touch
Ready to learn more about EZYGEL and how it can transform your practice? Our team is here to answer your questions and provide detailed information about this revolutionary technology.
Email Us
hello@trichogene.in
Call Us
+91 7097589786
Visit Us
Head Office (Research & Development)
Cosmogene Skincare Pvt Ltd
Life Science Incubation Centre,
IKP Knowledge Park, Genome Valley,
Turkapally, Hyderabad - 500101
Telangana, India
Cosmogene Skincare Pvt Ltd
Life Science Incubation Centre,
IKP Knowledge Park, Genome Valley,
Turkapally, Hyderabad - 500101
Telangana, India
Trichogene stands at the forefront of biotechnological innovation, dedicated to developing natural and effective solutions in regenerative medicine. As the pioneering force behind EZYGEL, we leverage decades of research and a commitment to scientific excellence to harness the body's intrinsic healing capabilities. Our mission is to empower practitioners with advanced, safe, and biologically compatible technologies.
Innovation
Driving progress through scientific discovery
Natural Solutions
Harnessing the body's own power to heal
Scientific Excellence
Backed by rigorous research and development